From RobinB., "The best book I've ever read," Angle of Repose by Wallace Stegner.
From the Penguin Group USA:
Angle of Repose tells the story of Lyman Ward, a retired professor of history and author of books about the Western frontier, who returns to his ancestral home of Grass Valley, California, in the Sierra Nevada. Wheelchair-bound with a crippling bone disease and dependent on others for his every need, Ward is nonetheless embarking on a search of monumental proportions—to rediscover his grandmother, now long dead, who made her own journey to Grass Valley nearly a hundred years earlier. Like other great quests in literature, Lyman Ward's investigation leads him deep into the dark shadows of his own life.